We want to become the undisputed leader in delivering Microbiome Ecosystem Therapies to treat moderate to severe dysbiosis in patients by mastering different modalities.
Enhancing Survival Through Innovative Immune Modulation
We restore and modulate patient-microbiome symbiosis
to improve survival in cancer.
Our vision
Our mission
We aim to develop, commercialize, and license innovative Microbiome medicines for patients with severe oncology diseases, using our full ecosystem modalities, on a global basis.
Our team
one of the world's most cited authors in the microbiome sphere today, after a professional career that spanned multiple industries. Hervé has led MaaT Pharma’s development from its early concept in 2013 and has been at the forefront of the development of the microbiome healthcare ecosystem in France and Europe. In January 2022, Hervé has been elected President of Allliance Promotion Microbiote, an organization founded in 2021 to support the microbiome sector development in France.
Engineer, MBA
PharmD
Eric is a senior financial executive with extensive experience in the biotech industry with companies listed on Euronext Paris and on the U.S. Nasdaq market. Prior to joining MaaT Pharma, Eric successfully conducted as CFO & COO of Erytech Pharma, a French late-stage drug development company, its Nasdaq IPO and subsequent financial rounds amounting to over EUR 300 million and supervised the scale-up of the company's operations from a single site based in France to a multi-site company of 240 employees in US and Europe and most recently its strategic merger. Throughout his 30-year career, Eric has developed a solid international experience across a variety of operational settings.
PhD in microbiology, Engineer in Agronomy, Genetics and Biotechnology
CPA, IFRS Certified
M.D. degree from the University of Pavia, Hematology fellowship at the University of Parma, and Ph.D. in Immunology from Paris-Sud University.
Academic research at Gustave Roussy and Memorial Sloan-Kettering Cancer Center.
Our Scientific Advisory Board
With more than 250 peer-reviewed manuscripts to his name, he is an expert in the field of Graft-vs-Host-Disease and was awarded the Van Bekkum Award, the highest award from the European Society for Stem Cell Transplantation.
His research includes clinical and translational studies on allogeneic hematopoietic stem cell transplantation with a particular focus on preclinical studies on GvHD and has published over 100 peer-reviewed manuscripts.
In 2021, Professor Mohty has been nominated a “Chevalier de la Légion d’Honneur”, the highest French award, and one of the world’s most widely recognized decorations.
MD, PhD
Co-Leader of the Melanoma and Skin Cancer SPORE
Co-Leader Cancer Immunology and Immunotherapy Program
PhD
MD
He studies how the intestinal microbiota interact with the host immune system as it relates to hematopoietic stem-cell transplantation, with a particular interest in graft-vs-tumor activity and graft-vs-host disease.
His long-term research goals include developing microbiota-based biomarkers that will be clinically useful in the care of transplant recipients, as well as microbiota-targeted therapeutic strategies to improve patient outcomes.
of Kremlin Bicêtre (Assistance Publique-Hôpitaux de Paris). He is specialized in inflammatory bowel disease care and research (clinical, epidemiological and translational). He is also
involved in care of patients with enterocolitis due to immune-checkpoint inhibitors and contributed to their description. He recently investigated the role of intestinal microbiota to predict response and intestinal toxicity of immune checkpoint inhibitors.
MD, PhD
Our Board of Directors
Based in the U.S., Karim Dabbagh, president and CEO of Second Genome Inc., renowned for his innovative work in microbiome science and former executive at Pfizer and Roche, brings extensive experience in pharmaceutical development.
PhD in Biochemistry from University College, London
BSc (Hons) in Biotechnology from Imperial College, London
She was formerly HR Director EMEA at Google and HR Director France at AOL.
Chief Corporate and People Operations Officer
Engineering degree Ecole Centrale Paris, MBA from Insead
one of the world's most cited authors in the microbiome sphere today, after a professional career that spanned multiple industries. Hervé has led MaaT Pharma’s development from its early concept in 2013 and has been at the forefront of the development of the microbiome healthcare ecosystem in France and Europe. In January 2022, Hervé has been elected President of Allliance Promotion Microbiote, an organization founded in 2021 to support the microbiome sector development in France.
Engineer, MBA
CFO
Graduated from HEC Paris and Bocconi University in Milan.
PharmD, PhD
Engineering degree from Ecole Centrale Paris
Doctorate in immuno-analysis and innovation in clinical biology - Sanofi Diagnostics Pasteur / CNRS.
Master's degree in Business Administration from IAE Poitiers.
Artificial Intelligence in Health University Diploma at Université Paris Cité.
Our CSR objectives
- Innovate and raise awareness to deliver better care,
- Contribute to employees-growth within a people-oriented ecosystem,
- Place ethics and transparency at the core of the Company’s strategy,
- Control and measure our impact on the environment.
Our history
-
2014
Incorporation of MaaT Pharma, based on INRAE technology
-
2015
Preclinical validation
+70% Reconstruction of the gut microbiota achieved, dose determination -
2016
Inauguration of the first GMP- compliant platform
€10 Million Serie A Financing Round
Proof of Concept Study (ODYSSEE) First AML patient treated with autologous FMT -
2017
Development of high richness and diversity pooled products
Partnerships with Biocodex and Bioaster
-
2018
Initiation of Phase II (HERACLES): MaaT013 in steroid refractory gastro-intestinal aGVHD patients after Allogenic HSCT
ODYSSEE Study showed 90% reconstruction in 25 patients
Proprietary medical device system received CE mark -
2019
Patent Portfolio expansion with 3 granted patents
MaaT013 Initial Early Access Program (EAP) data presented at ASH (n=8) -
2020
Series B completed
Additional EAP data presented (n=29)
Initiation of Phase I (CIMON): MaaT033 in hematology malignant Patients Under intensive Chemotherapy
Partnership with AP-HP -
2021
Announced positive HERACLES data
Additional promising EAP data presented at ASH (n=52)
Several positive DSMB decisions for CIMON
Listed on Euronext Paris - ticker MAAT -
2022
MaaT033: positive interim engraftment data - Phase 1b trial
Partnership with Skyepharma to establish the first exclusive Microbiome Ecosystem Therapies cGMP manufacturing facility in France
Hervé Affagard, CEO of MaaT Pharma, is elected President of Alliance Promotion Microbiote, the association federating key European players in the microbiome industry
MaaT013: Initiation of Phase 3 trial (ARES) in patients with aGvHD, the first Phase 3 trial globally for a microbiome-based therapy in haemato-oncology
Initiation of Phase 2a trial sponsored by AP-HP (PICASSO) evaluating MaaT013 in combination with Immune Checkpoint Inhibitors for patients with melanoma